4-[4-[(5S)-5-(Aminomethyl) -2-oxo-3-oxazolidinyl] phenyl] -3-morpholinone Hydrochloride
![4-[4-[(5S)-5-(Aminomethyl) -2-oxo-3-oxazolidinyl] phenyl]-3-morpholinone Hydrochloride Sawirka](http://cdn.globalso.com/jindunchem-med/dc3948321.jpg)
4-[4-[(5S)-5-(Aminomethyl) -2-oxo-3-oxazolidinyl] phenyl] -3-morpholinone Hydrochloride
12. Dhexdhexaadiyaha 4- (4-aminophenyl) -3-morpholinone (1) ee xinjirowga lidka ku ah rivaroxaban waxaa loo diyaariyey laba hab: 1, iyo wadarta wax-soo-saarka qiyaastii 32%;②Bromobenzene marka hore waa la nitrated, ka dibna waxaa lagu falceliyaa ethanolamine si loo helo 2- (4-nitroanilino) ethanol, kaas oo ka dibna lagu xiro chloroacetyl chloride.Dareen-celinta dhimista ayaa soo saarta 1, iyo wadarta wax-soo-saarku waa ilaa 47%.
Rivaroxaban waa nooc cusub oo ah daawada xinjirowga lidka ku ah oo si toos ah afka looga qaadan karo.Waxay si toos ah u joojisaa firfircoonida xinjirowga dhiigga Xa, waxay leedahay saameyn go'an oo ka hortag ah, uma baahna kormeer joogto ah, waxayna leedahay badbaado sare.Codsiga kiliinikada ee rivaroxaban, Baahida loo qabo rivaroxaban ayaa si tartiib tartiib ah u kordheysa.Magaca kiimikada ee rivaroxaban waa 5-chloro-N-(((5S) -2-oxo-3-[4- (3-oxo- 4-morpholinyl) phenyl)-1,3-oxazolidine-5-yl) methyl -2-thiophenecarboxamide.Hadda waxa jira laba dariiq oo synthetic ah oo laga soo sheegay suugaanta, labada waddoba waxa la isticmaalaa dhexdhexaad 4-(4-aminophenyl) -3-morpholinone.Inkasta oo ay jiraan warbixino ku saabsan isku-dhafka 4- (4-aminophenyl) -3-morpholinone gudaha iyo dibaddaba, waxaa jira qiimo aad u sarreeya oo ah alaabta ceeriin ee falcelinta.Sare, ay adagtahay in la iibsado, ama shuruudaha hawlgalka falcelinta ayaa aad u sarreeya, adag in la fahmo, aan ku habboonayn ilaalinta deegaanka iyo cilladaha kale, oo aan buuxin shuruudaha wax-soo-saarka ballaaran ee warshadaha.Hagaajinta dhexdhexaadiyaha muhiimka ah ee rivaroxaban 4- (4-aminophenyl) - Habka wax soo saarka ee 3-morpholinone iyo dhimista qiimaha alaabta ceeriin ayaa hubaal ah inay kor u qaadi doonto horumarinta iyo codsiga rivaroxaban.Ma jiro wax warbixin ah oo ku saabsan isku-dhafka rivaroxaban ee Shiinaha.Waxaan joognaa Rivaroxaban Dhexdhexaadiyaha muhiimka ah ee 4-(4-aminophenyl) -3-morpholinone synthetic dariiqa iyo tignoolajiyada si halabuur leh ayaa loo darsay.Laba bromobenzene iyo p-nitrobromobenzene sida alaabta bilowga ah ayaa la soo jeediyay.Dariiqa loo maro.Diirada saar habka baaskiilka ee giraanta 3-morpholinone.
Heerka fulinta:heerka ganacsiga
Dibadda:Budada crystalline cad
Xidhmada:25kg/durbaan
assay (HPLC) ka kooban ama ka weyn 98.0%
JIN DUN Medical ayaa lehShahaadada ISO oo buuxisa heerarka wax soo saarka GMP, la shaqaaleysiiyay khubarada isku dhafka daroogada ee gudaha iyo dibadda oo leh khibrad qani ah si ay u hagaan R&D ee shirkadda.
TECHNOL OGY FAA'IIDOOYINKA
●Cadaadiska Sare ee Katalytic Hydrogenation.Cadaadiska Sare ee Hydrogenolysis Falcelinta .Falcelinta Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
● Falcelinta dib u habeynta
●Go'aanka Chiral
●Heck, Suzuki,Negishi,Sonogashira .Falcelinta Gignard
Qalabka
Shaybaadhkayagu waxa uu leeyahay qalab tijaabo ah oo kala duwan, sida: NMR (Bruker 400M),HPLC,chiral-HPLC,LC-MS,LC-MS/MS (API 4000),IR,UV,GC,GC-MS, Chromatography, Mikrowave Synthesizer, Parallel Synthesizer, Kalorimitirka Iskaanka Kala Duwan (DSC), Microscope Electron...
Kooxda R&D
Jindun Medical waxay leedahay koox shaqaale R&D ah oo xirfad leh, waxayna shaqaaleysiisaa khubaro badan oo gudaha iyo dibedda ah oo ku takhasusay isku-darka daroogada si ay u hagaan R&D, taasoo ka dhigaysa isku-dhafkayaga mid sax ah oo hufan.
Waxaan caawinay dhowr shirkadood oo dawooyinka gudaha ugu sarreeya, sidaHansoh, Hengrui iyo HEC Pharm.Halkan waxaan ku tusi doonaa qayb iyaga ka mid ah.
Kiiska Koowaad ee Customization:
Cas No.: 110351-94-5
Cabashada Labaad:
Cas No.: 144848-24-8
Kiiska Saddexaad ee Habaynta:
Cas No.: 200636-54-0
1.Habbee Dhexdhexaadiyeyaasha Cusub ama API-yada.Si la mid ah wadaagista kiisaska kore, macaamiishu waxay leeyihiin dalabaadka Dhexdhexaadiyeyaasha gaarka ah ama API-yada, mana ka heli karaan badeecadaha loo baahan yahay suuqa, ka dib waxaan ku caawin karnaa si aan u habeyno.
2.Habraaca Hagaajinta Alaabta Hore.Kooxdayadu waxay gacan ka geysan doontaa in ay wanaajiso oo ay hagaajiso wax soo saarka noocaas ah oo dariiqa falcelinta ee duugoobay, qiimaha wax soo saarku uu sarreeyo, waxtarkeeduna uu yar yahay.Waxaan ku siin karnaa dukumeenti buuxa oo wareejinta tignoolajiyada iyo hagaajinta habka, ka caawinta macaamiisha wax soo saar hufan.
Laga soo bilaabo bartilmaameedyada daroogada ilaa INDs, JIN DUN Medical ayaa ku siinaysaXalka R&D shaqsiyeysan ee hal-joojin ah.
JIN DUN Medical waxay ku adkaysanaysaa abuurista koox riyooyin leh, samaynta alaab sharaf leh, taxadar leh, adag, iyo u bixista dhammaan si ay u noqoto lammaane la aamini karo iyo saaxiibka macaamiisha!
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