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8-Bromo-7-laakin-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylmethyl) -3

8-Bromo-7-laakin-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylmethyl) -3

Sharaxaad Gaaban:

Qaacidada molecular:C20H17BrN6O2

Miisaanka molecular:453.29

CAS maya:853029-57-9


Faahfaahinta Alaabta

Tags Product

Codsiga

Isticmaal:Dhexdhexaad u ah Linagliptin.

Isticmaal:Dhexdhexaad u ah Linagliptin
Heerka fulinta:heerka ganacsiga
Qiimaynta:98-102%

Dibadda:Caddaan ilaa budo huruud ah oo khafiif ah
Xidhmada:25kg/durbaan

Ujeedo

Si loo falanqeeyo linagliptin-ka jira iyo furaha dhexe ee 8-bromo-7- (2-butynyl) -3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl) methyl) -1H-purine- 2,6-dione (11) habka synthesis, hel waddo synthetic ah oo ku habboon wax soo saarka warshadaha.Habka: soo koob waddooyinka kala duwan ee synthetic.Natiijooyinka iyo gabagabada: Marinka 2.2 wuxuu leeyahay hannaan fudud iyo kharash yar, kaas oo ku habboon wax soo saarka warshadaha.

8-bromo-3,7-dihydro-3-methyl-1H-purine-2,6-dione waa dhex dhexaad muhiim ah oo ka mid ah isku dhafka daawada hypoglycemic linagliptin.Isku-dubarid 1 waxay isticmaashaa methyl urea iyo cyanoacetic acid sida alaabta bilawga ah, waxayna martaa falcelinta lix-tallaabo ee uumiga, wareegga wareegga, nitrosation, hoos u dhigista, wareegga wareegga, iyo bromine oo leh wadarta guud ee 46.3%.Qaab dhismeedka dhammaan dhexdhexaadiyeyaasha waxaa xaqiijiyay 1HNMR.

Hal-abuurka hadda wuxuu la xiriiraa habka diyaarinta fudud ee linagliptin-nadiifinta sare leh.Quinazoline, dhex dhexaadiyaha muhiimka ah ee diyaarinta hal-dhari ee linagliptin 8 bromo 7 (2 butyne 1 base) 3,7 dihydro 3 methyl 1 [(4 methyl 2 quinazolinyl) methyl] 1H Purine 2,6 dione, dhexda waxaa loo kala saaraa sifaynta, ka dibna ku falcelisa (R)3 aminopiperidine dihydrochloride si loo helo xal ka kooban linagliptin.Ka dib markii xalka uu ku jiro linagliptin mar kale la farsameeyo, Deliraliptin badeeco saafi ah.Diyaarinta dhex-dhexaadka muhiimka ah ee wax-soo-saarka hadda jira wuxuu qaataa hab hal-dheri ah, kaas oo ku habboon in la shaqeeyo oo hagaajiyo wax-soo-saarka.Ka dib marka dhexdhexaadiyaha muhiimka ah la kala saaro, waxaa lagu falceliyaa (R) 3 aminopiperidine dihydrochloride, sidaas darteed Helitaanka linagliptin nadiif ah oo sarreeya waxay sidoo kale buuxisaa shuruudaha wax soo saarka iyo caddaynta ee shirkadaha dawooyinka.

Khadka Alaabta isku-dhafan

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Shahaado

JIN DUN Medical ayaa lehShahaadada ISO oo buuxisa heerarka wax soo saarka GMP, la shaqaaleysiiyay khubarada isku dhafka daroogada ee gudaha iyo dibadda oo leh khibrad qani ah si ay u hagaan R&D ee shirkadda.

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Faa'iidooyinka Isbeddelka Caafimaadka

TECHNOL OGY FAA'IIDOOYINKA
●Cadaadiska Sare ee Katalytic Hydrogenation.Cadaadiska Sare ee Hydrogenolysis Falcelinta .Falcelinta Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
● Falcelinta dib u habeynta
●Go'aanka Chiral
●Heck, Suzuki,Negishi,Sonogashira .Falcelinta Gignard

JIN DUN R&D

Qalabka

Shaybaadhkayagu waxa uu leeyahay qalab tijaabo ah oo kala duwan, sida: NMR (Bruker 400M),HPLC,chiral-HPLC,LC-MS,LC-MS/MS (API 4000),IR,UV,GC,GC-MS, Chromatography, Mikrowave Synthesizer, Parallel Synthesizer, Kalorimitirka Iskaanka Kala Duwan (DSC), Microscope Electron...

Kooxda R&D

Jindun Medical waxay leedahay koox shaqaale R&D ah oo xirfad leh, waxayna shaqaaleysiisaa khubaro badan oo gudaha iyo dibedda ah oo ku takhasusay isku-darka daroogada si ay u hagaan R&D, taasoo ka dhigaysa isku-dhafkayaga mid sax ah oo hufan.

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Dacwad- Wadaag

Waxaan caawinay dhowr shirkadood oo dawooyinka gudaha ugu sarreeya, sidaHansoh, Hengrui iyo HEC Pharm.Halkan waxaan ku tusi doonaa qayb iyaga ka mid ah.

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Kiiska Koowaad ee Customization:

Cas No.: 110351-94-5

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Cabashada Labaad:

Cas No.: 144848-24-8

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Kiiska Saddexaad ee Habaynta:

Cas No.: 200636-54-0

Habka iskaashiga

1.Habbee Dhexdhexaadiyeyaasha Cusub ama API-yada.Si la mid ah wadaagista kiisaska kore, macaamiishu waxay leeyihiin dalabaadka Dhexdhexaadiyeyaasha gaarka ah ama API-yada, mana ka heli karaan badeecadaha loo baahan yahay suuqa, ka dib waxaan ku caawin karnaa si aan u habeyno.

2.Habraaca Hagaajinta Alaabta Hore.Kooxdayadu waxay gacan ka geysan doontaa in ay wanaajiso oo ay hagaajiso wax soo saarka noocaas ah oo dariiqa falcelinta ee duugoobay, qiimaha wax soo saarku uu sarreeyo, waxtarkeeduna uu yar yahay.Waxaan ku siin karnaa dukumeenti buuxa oo wareejinta tignoolajiyada iyo hagaajinta habka, ka caawinta macaamiisha wax soo saar hufan.

Laga soo bilaabo bartilmaameedyada daroogada ilaa INDs, JIN DUN Medical ayaa ku siinaysaXalka R&D shaqsiyeysan ee hal-joojin ah.

JIN DUN Medical waxay ku adkaysanaysaa abuurista koox riyooyin leh, samaynta alaab sharaf leh, taxadar leh, adag, iyo u bixista dhammaan si ay u noqoto lammaane la aamini karo iyo saaxiibka macaamiisha!


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