Casp ungin Acetate;Caspofungin acetate;Candidas;Caspofungin acetate [USAN:BAN:JAN];
![Casp ungin Acetate;Caspofungin acetate;Candidas;Caspofungin acetate [USAN:BAN:JAN];Sawirka Muuqda](http://cdn.globalso.com/jindunchem-med/fbe17385.jpg)
Casp ungin Acetate;Caspofungin acetate;Candidas;Caspofungin acetate [USAN:BAN:JAN];
Waxqabadka Nafleyda ee Caspofungin Acetate
| Sharax | Caspofungin Acetate waa daawada fangas-ka-hortagga ah oo si aan tartan lahayn u joojin karta isku-darka 1,3-β-d glucan synthase. |
| la xidhiidhaqaybaha | Jidka calaamadaha >> Anti-infective >> Fungus Meelaha cilmi-baarista >> Fayraska |
| In vivocilmi baaris | Jiirarka lagu duray caspofungin wax isbeddel ah oo la taaban karo kuma yeelan qaabkooda mowjadda ERG marka la eego fiirsashada vitreous ee 0.41 ilaa 4.1 μM, iyo retina ma lahayn isbeddello muuqaal ah oo la ogaan karo ama luminta unugga.Marka la eego fiirsashada vitreous ee 41 μM, caspofungin waxay hoos u dhigtay baaxadda hirarka, hirarka b iyo jawaabta marinka scotopic ee ERG, waxayna sidoo kale sababtay hoos u dhaca tirada unugyada lakabka unugyada ganglion [1].Carprofungin (8 mg / kg) ama amphotericin B 1 mg / kg, cirbadeynta intraperitoneal hal mar maalintii 30 saacadood ka dib caabuqa 7 maalmood oo isku xigta, marka loo eego daaweynta xakamaynta baabuurta, 100% badbaadada maalinta 28, taasoo keentay maalinti 100% heerka dhimashada 11 , ka dib markii loolan infekshanka ah.Marka la barbardhigo daawaynta xakamaynta gaadiidka ee maalinta 5, caspofungin waxay hoos u dhigtay dib u soo kabashada Candida ee suurtogalka ah ee kelyaha iyo unugyada maskaxda marka culeyska xakamaynta uu gaaro heerkiisa ugu sarreeya.Jiirarka lagu daweeyay caspofungin ee qiyaasta 2 mg/kg ama ka sareeya ayaa culayska maskaxda si aad ah uga hooseeya maalintii 5 marka loo eego jiirarka lagu daweeyay amphotericin B. Amphotericin B iyo daawaynta caspofungin waxay hoos u dhigtay culayska fangas ee kelyaha 1.7 log CFU/g iyo 2.46 ilaa 3.64 log CFU /g, siday u kala horreeyaan [2]. |
| Xoolahatijaabo | Daaweyn antifungal ah ayaa la bilaabay 30 saacadood ka dib caqabada infekshanka waxaana lagu mudi jiray intraperitoneal (ip) duritaan hal mar maalintii muddo 7 maalmood ah.Jiirarka waxaa lagu daweeyay 1, 2, 4, ama 8 mg/kg/maalin caspofungin, 1 mg/kg/maalin amphotericin B ama kontoroolka gaariga (biyo nadiif ah oo nadiif ah).Waxtarka qaabka waxaa lagu qiimeeyay saddex siyaabood: iyada oo la kormeerayo heerka badbaadada ee 10 xayawaanka ee koox kasta oo daaweyn ah, iyada oo la kormeerayo culeyska Candida ee kelyaha iyo unugyada maskaxda ee kooxda labaad ee xayawaanka la daweeyay, iyo iyada oo si taariikhi ah loo qiimeeyo kelyaha.Iyo maskaxda.Kooxda saddexaad ee xoolaha la daweeyay.Jiirarka waxaa lagu nadiifiyey CO 2 neefsasho waxaana lagu dhaqay 30 saacadood (koontoroolka baabuurka lagu daaweeyay oo keliya) iyo maalinta 5 (24 saacadood ka dib qiyaasta 4aad), 8 (24 saacadood ka dib qiyaasta ugu dambeysa), iyo 14, 21 saacadood iyo histological muunad unug.(Kaliya daaweynta caspofungin), iyo 28 ka dib weerarka. |
| Tixraacyo | [1]Mojumder DK, iyo al.Qiimaynta sunta isha ee caspofungin intravitreal ee isha jiirka.Maalgelinta Ophthalmol Vis Sci.2010 Nov; 51 (11): 5796-803. [2].Flattery, Amy M. et al.Waxtarka caspofungin ee qaabka jiirka dhalinyarada ee habka dhexe ee neerfayaasha candidiasis.Wakiilada Kahortagayaasha Ka-hortagga Ah iyo Chemotherapy (2011), 55(7), 3491-3497. |
Waxyaabaha kiimikaad iyo jireed ee caspofungin acetate
| Barta karkarinta | 1408.1ºC at 760 mmHg |
| qaacidada molecular | C56H96N10O19 |
| Miisaanka molecular | 1093.31000 |
| Tayada saxda ah | 1092.64000 |
| PSA | 412.03000 |
| LogP | 0.06150 |
| Astaamaha muuqaalka | caddaan ilaa beige |
| Cadaadiska uumiga | 0mmHg at 25°C |
| Xaaladaha kaydinta | 20°C |
| Biyuhu milma | H2O: milma15mg/mL (xal cad) |
Kastamka Caspofungin Acetate
| Koodhka kastamka | 2933990099 |
| Dulmarka Shiinaha | 2933990099. Xeryaha kale ee heterocyclic oo ay ku jiraan heteroatoms nitrogen oo kaliya.Qiimaha canshuurta lagu daray: 17.0%.Heerka dhimista canshuurta: 13.0%.Shuruudaha sharciyeed: Midna.Tacriifada qaranka ee ugu caansan: 6.5%.Qiimaha guud: 20.0% |
| Qodobbada caddaynta | Magaca badeecada, waxyaabaha ka kooban, isticmaalka, hexamethylene chloride, fadlan muuji muuqaalka, 6-caprolactam, fadlan muuji muuqaalka, taariikhda saxeexa |
| Soo koobid | 2933990090. Xeryahooda heterocyclic oo leh nitrogen hetero-atom(yada) kaliya.VAT: 17.0%.Heerka dhimista canshuurta: 13.0%..Qiimaha MFN:6.5%.Qiimaha guud: 20.0% |
Habka wax soo saarka
Caspofungin wuxuu u baahan yahay in lagu diyaariyo halsano teknoolajiyada semi-synthetic.Badeecada cayriin ee giraanta ugu weyn waxay u baahan tahay in lagu helo tignoolajiyada halsano, ka dibna badeecada dhexdhexaadka ah waxaa lagu helaa kala-soocidda iyo nadiifinta, ka dibna badeecada dhexdhexaadka ah waxaa loo isticmaalaa sida alaabta bilawga ah si loo dhamaystiro silsiladda dhinaca iyadoo la adeegsanayo tignoolajiyada synthetic si ugu dambeyntii loo helo. Cunsurka la beegsanayo.Sababtoo ah alaabooyinka "synthetic semi-synthetic" waxay u baahan yihiin inay maraan xiriiro farsamo oo badan sida halsano, kala-soocid iyo sifeyn, iwm., dariiqa farsamada iyo xakamaynta halbeegyada habka ayaa aad ugu dhib badan Buuga Kiimikada.Intaa waxaa dheer, shuruudaha sharciyeynta ee diiwaangelinta caspofungin, oo ah wax soo saarka semi-synthetic, ayaa sidoo kale aad u sarreeya.Dukumeentiyada codsigu waxay u baahan yihiin inay ka soo bilowdaan isha halsano, ma aha oo kaliya in si habaysan loo barto beerista culayska, tignoolajiyada halsano, iyo tignoolajiyada sifaynta, laakiin sidoo kale si loo sahamiyo habka isku-dhafka.Jidka, xaaladaha, iyo xakamaynta wasakhda ee habka, sababtoo ah sheyga kama dambaysta ah waa mid jilicsan, taxadar la'aan kasta ayaa tirtiri doonta dhammaan dadaalladii hore, iyo dhibaatada farsamada iyo kharashka maaha mid muhiim ah.
Si sax ah waa sababta oo ah caqabadaha farsamada sare iyo muuqaalka tartanka wanaagsan ee Hengrui Caspofungin ay ilaalisay meel qiimo fiican leh ka dib liiskeeda.
Ilaalinta patent-ka ayaa dhacday 2014-kii
Iibinta duritaanka caspofungin terminal ee xarumaha caafimaadka dadweynaha ee Shiinaha (cutub: toban kun oo yuan)
Ilaa hadda, kaliya daawooyinka guud ee Hengrui Pharmaceuticals, Chia Tai Tianqing, Borui Pharmaceuticals, iyo Haisco ayaa loo oggolaaday liiska.Huadong Medicine?
Shirkadda asalka ah ee cilmi-baarista ee caspofungin acetate waa Merck, iyo liiska codsiyada 6 ee shirkadaha ayaa dib u eegis ku socda oo la ansixiyay, kuwaas oo ah Qilu Pharmaceutical, Nanjing Yinxing Pharmaceutical, Pharmaceutical Sihuan, Osaikang Pharmaceutical, Sino-US Huadong Pharmaceutical, iyo Tianceuticals Biopharmaceutical.
JIN DUN Medical ayaa lehShahaadada ISO oo buuxisa heerarka wax soo saarka GMP, la shaqaaleysiiyay khubarada isku dhafka daroogada ee gudaha iyo dibadda oo leh khibrad qani ah si ay u hagaan R&D ee shirkadda.
TECHNOL OGY FAA'IIDOOYINKA
●Cadaadiska Sare ee Katalytic Hydrogenation.Cadaadiska Sare ee Hydrogenolysis Falcelinta .Falcelinta Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
● Falcelinta dib u habeynta
●Go'aanka Chiral
●Heck, Suzuki,Negishi,Sonogashira .Falcelinta Gignard
Qalabka
Shaybaadhkayagu waxa uu leeyahay qalab tijaabo ah oo kala duwan, sida: NMR (Bruker 400M),HPLC,chiral-HPLC,LC-MS,LC-MS/MS (API 4000),IR,UV,GC,GC-MS, Chromatography, Mikrowave Synthesizer, Parallel Synthesizer, Kalorimitirka Iskaanka Kala Duwan (DSC), Microscope Electron...
Kooxda R&D
Jindun Medical waxay leedahay koox shaqaale R&D ah oo xirfad leh, waxayna shaqaaleysiisaa khubaro badan oo gudaha iyo dibedda ah oo ku takhasusay isku-darka daroogada si ay u hagaan R&D, taasoo ka dhigaysa isku-dhafkayaga mid sax ah oo hufan.
Waxaan caawinay dhowr shirkadood oo dawooyinka gudaha ugu sarreeya, sidaHansoh, Hengrui iyo HEC Pharm.Halkan waxaan ku tusi doonaa qayb iyaga ka mid ah.
Kiiska Koowaad ee Customization:
Cas No.: 110351-94-5
Cabashada Labaad:
Cas No.: 144848-24-8
Kiiska Saddexaad ee Habaynta:
Cas No.: 200636-54-0
1.Habbee Dhexdhexaadiyeyaasha Cusub ama API-yada.Si la mid ah wadaagista kiisaska kore, macaamiishu waxay leeyihiin dalabaadka Dhexdhexaadiyeyaasha gaarka ah ama API-yada, mana ka heli karaan badeecadaha loo baahan yahay suuqa, ka dib waxaan ku caawin karnaa si aan u habeyno.
2.Habraaca Hagaajinta Alaabta Hore.Kooxdayadu waxay gacan ka geysan doontaa in ay wanaajiso oo ay hagaajiso wax soo saarka noocaas ah oo dariiqa falcelinta ee duugoobay, qiimaha wax soo saarku uu sarreeyo, waxtarkeeduna uu yar yahay.Waxaan ku siin karnaa dukumeenti buuxa oo wareejinta tignoolajiyada iyo hagaajinta habka, ka caawinta macaamiisha wax soo saar hufan.
Laga soo bilaabo bartilmaameedyada daroogada ilaa INDs, JIN DUN Medical ayaa ku siinaysaXalka R&D shaqsiyeysan ee hal-joojin ah.
JIN DUN Medical waxay ku adkaysanaysaa abuurista koox riyooyin leh, samaynta alaab sharaf leh, taxadar leh, adag, iyo u bixista dhammaan si ay u noqoto lammaane la aamini karo iyo saaxiibka macaamiisha!
