FondaparinSodiuM; Fondaparinux SodiuM Aqoonsiga; Fondaparinux sodium N-4;
FondaparinSodiuM; Fondaparinux SodiuM Aqoonsiga; Fondaparinux sodium N-4;
Waxqabadka noolaha ee Fondaparinux
| Sharax | Fondaparinux sodium waa antithrombin-ku-tiirsanaanta Xa inhibitor. |
| la xidhiidhaQaybaha | Jidka calaamadda >> Enzymes dheef-shiid kiimikaadka/proteases >> Factor Xa meelaha cilmi baarista >> Cudurrada wadnaha |
| Bartilmaameedka | Sababta Xa[1] |
| In vitrowaxbarashada | Fondaparinux sodium waa daawada xinjirowga lidka ku ah ee ugu horreysa ee si door ah u bartilmaameedsata factor Xa.Fondaparinux, qiimaha IC50 (anti-Xa IU / ml) ee monocytes firfircoon (ac-M) waa 0.59 ± 0.05, iyo walxaha monocyte-derived (MMP) waa 0.17 ± 0.03 [2]. |
| In vivocilmi baaris | Fondaparinux sodium waxay leedahay qaab toosan, oo qiyaasta daawada farmashiyaha ku tiirsan, taas oo bixisa jawaab aad loo saadaalin karo.Fondaparinux sodium waxay leedahay 100% bioavailability, waxay leedahay bilaw degdeg ah oo ficil ah, waxay leedahay nolol badhkeed 14 ilaa 16 saacadood, waxayna sii wadi kartaa iska caabinta xinjirowga 24 saacadood gudahood.Daawadu wax saameyn ah kuma yeelanayso wakhtiga prothrombin ama qayb qayb ah oo thromboplastin ah oo firfircoon, mana saamayso shaqada platelet ama isu geynta [1]. |
| Tixraacyo | [1]Bauer KA.iyo al.Fondaparinux sodium: xakameynta xulashada Xa.Am J Health System Pharm2001 Nof 1;58 Suppl 2: S14-7.[2].Ben-Hadj-Khalifa S, iyo al.Saamaynta xakamaynta xinjirowga kala duwan ee fondaparinux, enoxaparin iyo heparin aan jajabnayn ee moodooyinka unugyada jiilka thrombin.Dhiiga Xididada Fibrinolysis.2011 Jul;22(5):369-73. |
Waxyaabaha kiimikada iyo jirka ee Fondaparinux
| qaacidada molecular | C31H53N3Na10O49S8 |
| Miisaanka molecular | 1738.16 |
| PSA | 900.82000 |
Fondaparinux waa nooc cusub oo daawada xinjirowga lidka ku ah oo ay ansixisay FDA ka dib heparin iyo heparin miisaanka kelli ee hooseeya ee daaweynta iyo ka hortagga noocyada kala duwan ee xinjirowga xididada.
Tilmaamaha: Fondaparinux waxaa loo isticmaalaa bukaanada lagu sameeyo qalliinka weyn ee lafaha lugaha hoose, sida miskaha jabka, qalliinka weyn ee jilibka ama beddelka miskaha, si looga hortago xinjirowga xididka.Waxaa loo isticmaalaa daawaynta bukaanada qaba angina aan degganayn ama wadnaxanuun myocardial-ka aan-ST-qaybta ahayn kuwaas oo si degdeg ah (<120 daqiiqo) daawaynta invasive (PCI) la tilmaamo.Waxaa loo isticmaalaa daawaynta bukaanada qaba wadnaxanuun myocardial kor u kaca qaybta ST ee isticmaala thrombolysis ama aan marka hore helin noocyo kale oo daawaynta reperfusion.
1) Kor u qaadista suuqa ee Glaxo waxay gelin doontaa booska ugu muhiimsan ee dawada ee dariiqa caafimaad ee xiga ee Wasaaradda Caafimaadka, dib-u-habaynta qiimaha ee Komishanka Horumarinta iyo Dib-u-habaynta Qaranka, iyo caymiska caafimaadka ee Wasaaradda Caymiska Dadweynaha.
A, Alaabta weli ma gelin caymiska caafimaadka qaranka.Sannadkii 2010, isbeddelka caymiska caafimaadku wuxuu hadda galay caymiska caafimaadka ee 16 gobol.Iibku wuxuu ku jiraa marxaladda hore wuxuuna si tartiib tartiib ah u beddeli doonaa suuqa heparin-miisaanka hooseeya;gobollada caymiska caafimaadka: Shaanxi, Shanxi, Mongolia gudaha, Liaoning, Tibet, Yunnan, Guangdong , Guangxi, Hainan, Jiangsu, Gansu, Fujian, Jiangxi, Henan, Hubei, Beijing.
B, Astaamaha ayaa wali sii kordhaya.GSK hadda waxay rugta caafimaadka ku leedahay 3 calaamadood.Tusaale ahaan, tilmaamaha stent-yada si gaar ah ayaa loo ansixiyay.Heparin kale lama heli karo.Codsiga bukaan-socodka ee stent wuxuu kordhiyaa 30% sannad kasta.Marka la oggolaado calaamado cusub, iibku wuu kordhin doonaa.Aragti ahaan, dhammaan cudurrada lagu daweeyo alaabooyinka taxanaha heparin waxaa lagu daweyn karaa alaabtan.
C, Faa'iidada qiimaha, qiimaha ugu yar ee wax soo saarka this ee suuqa Maraykanka waa 132 US dollars kasta, ee Shiinaha waa 168 yuan, qiimaha gudaha ma dhici doono.Haddii aad dhoofiso, suuqa caalamiga ahi waxa uu leeyahay meel ballaadhan;
2) Xadka farsamo ayaa sarreeya, alaabta ceeriin waxaa lagu farsameeyay 75 tillaabo, patent-kuna wuxuu dhacay 5 sano (qodob 2014).Ma aysan ansixin shirkado kale.Laydhisku waa mid aad u adag.Laguma samayn doono wax ka yar 10 sano.Wareeggu waa mid dheer, adag, iyo maalgashi.sareWaxaa jira tartamayaal gudaha ah oo yar, iyo tartamayaasha ajnabiga ah waxay leeyihiin kharashyo cayriin ah oo sarreeya.Hadafkayagu waa inaan si joogto ah u dhimno kharashyada alaabta ceeriin oo aan ku beddelno Glaxo wax soo saarka alaabta ceeriin.
Hengrui Pharmaceuticals Fondaparinux waxaa loo ansixiyay ku dayashada ugu horreysa ee Shiinaha 2018.
Guangdong Runxing Biotechnology Co., Ltd. waxay leedahay wax soo saar sanadle ah oo ah 210 kg ee fondaparinux sodium dhexdhexaadiyaha sare ee N3, kaas oo la xarayn doono 2018.
Fondaparinux waxaa markii hore soo saartay MYLAN IRELAND.Hadda, Hengrui Pharmaceuticals, Borui Pharmaceuticals, Haisco.
JIN DUN Medical ayaa lehShahaadada ISO oo buuxisa heerarka wax soo saarka GMP, la shaqaaleysiiyay khubarada isku dhafka daroogada ee gudaha iyo dibadda oo leh khibrad qani ah si ay u hagaan R&D ee shirkadda.
TECHNOL OGY FAA'IIDOOYINKA
●Cadaadiska Sare ee Katalytic Hydrogenation.Cadaadiska Sare ee Hydrogenolysis Falcelinta .Falcelinta Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
● Falcelinta dib u habeynta
●Go'aanka Chiral
●Heck, Suzuki,Negishi,Sonogashira .Falcelinta Gignard
Qalabka
Shaybaadhkayagu waxa uu leeyahay qalab tijaabo ah oo kala duwan, sida: NMR (Bruker 400M),HPLC,chiral-HPLC,LC-MS,LC-MS/MS (API 4000),IR,UV,GC,GC-MS, Chromatography, Mikrowave Synthesizer, Parallel Synthesizer, Kalorimitirka Iskaanka Kala Duwan (DSC), Microscope Electron...
Kooxda R&D
Jindun Medical waxay leedahay koox shaqaale R&D ah oo xirfad leh, waxayna shaqaaleysiisaa khubaro badan oo gudaha iyo dibedda ah oo ku takhasusay isku-darka daroogada si ay u hagaan R&D, taasoo ka dhigaysa isku-dhafkayaga mid sax ah oo hufan.
Waxaan caawinay dhowr shirkadood oo dawooyinka gudaha ugu sarreeya, sidaHansoh, Hengrui iyo HEC Pharm.Halkan waxaan ku tusi doonaa qayb iyaga ka mid ah.
Kiiska Koowaad ee Customization:
Cas No.: 110351-94-5
Cabashada Labaad:
Cas No.: 144848-24-8
Kiiska Saddexaad ee Habaynta:
Cas No.: 200636-54-0
1.Habbee Dhexdhexaadiyeyaasha Cusub ama API-yada.Si la mid ah wadaagista kiisaska kore, macaamiishu waxay leeyihiin dalabaadka Dhexdhexaadiyeyaasha gaarka ah ama API-yada, mana ka heli karaan badeecadaha loo baahan yahay suuqa, ka dib waxaan ku caawin karnaa si aan u habeyno.
2.Habraaca Hagaajinta Alaabta Hore.Kooxdayadu waxay gacan ka geysan doontaa in ay wanaajiso oo ay hagaajiso wax soo saarka noocaas ah oo dariiqa falcelinta ee duugoobay, qiimaha wax soo saarku uu sarreeyo, waxtarkeeduna uu yar yahay.Waxaan ku siin karnaa dukumeenti buuxa oo wareejinta tignoolajiyada iyo hagaajinta habka, ka caawinta macaamiisha wax soo saar hufan.
Laga soo bilaabo bartilmaameedyada daroogada ilaa INDs, JIN DUN Medical ayaa ku siinaysaXalka R&D shaqsiyeysan ee hal-joojin ah.
JIN DUN Medical waxay ku adkaysanaysaa abuurista koox riyooyin leh, samaynta alaab sharaf leh, taxadar leh, adag, iyo u bixista dhammaan si ay u noqoto lammaane la aamini karo iyo saaxiibka macaamiisha!
