Tayada wanaagsan 99% 2-Cyanobenzyl Bromide;Alpha-Bromo-O-Toluonitrile CAS: 22115-41-9

Kaliya isku dayi mayno inteena ugu weyn si aan u siino shirkado heer sare ah iibsade kasta, laakiin sidoo kale waxaan diyaar u nahay inaan helno talo kasta oo ay bixiyaan dukaamaystayaasheena tayada Wanaagsan 99% 2-Cyanobenzyl Bromide;Alpha-Bromo-O-Toluonitrile CAS: 22115-41-9, Kooxda shirkadeena oo ay weheliso adeegsiga tignoolajiyada casriga ah waxay soo bandhigaan badeecado tayo leh oo tayo sare leh oo si heer sare ah loo jecel yahay loona qadariyo rajadayada adduunka oo dhan.
Ma isku dayi doono oo kaliya in aan u bandhigno shirkado heer sare ah wax iibsade kasta, laakiin sidoo kale waxaan diyaar u nahay inaan helno talo kasta oo ay bixiyaan dukaamaystayaasheenaShiinaha 2-Cyanobenzyl Bromide Powder iyo Alpha-Bromo-O-Toluonitrile, Waxaan si adag u aaminsanahay in tignoolajiyada iyo adeegyadu ay yihiin saldhiggayaga maanta tayada ayaa abuuri doonta gidaaradayada mustaqbalka ee la isku halayn karo.Kaliya waxaan leenahay tayo ka wanaagsan oo ka sii fiican, ma gaari karnaa macaamiisheena iyo nafteena, sidoo kale.Ku soo dhawoow macaamiisha ereyga oo dhan si aad nala soo xiriirto si aad u hesho ganacsi dheeraad ah iyo xiriiro la isku halayn karo.Waxaan had iyo jeer halkan joognay ka shaqaynta dalabaadkaaga mar kasta oo aad u baahan doonto.

Isticmaal:Dhexdhexaad u ah Linagliptin.

Isticmaal:Dhexdhexaad u ah Linagliptin
Heerka fulinta:heerka ganacsiga
Qiimaynta:98-102%

Dibadda:Caddaan ilaa budo huruud ah oo khafiif ah
Xidhmada:25kg/durbaan

Si loo falanqeeyo linagliptin-ka jira iyo furaha dhexe ee 8-bromo-7- (2-butynyl) -3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl) methyl) -1H-purine- 2,6-dione (11) habka synthesis, hel waddo synthetic ah oo ku habboon wax soo saarka warshadaha.Habka: soo koob waddooyinka kala duwan ee synthetic.Natiijooyinka iyo gabagabada: Marinka 2.2 wuxuu leeyahay hannaan fudud iyo kharash yar, kaas oo ku habboon wax soo saarka warshadaha.

8-bromo-3,7-dihydro-3-methyl-1H-purine-2,6-dione waa dhex dhexaad muhiim ah oo ka mid ah isku dhafka daawada hypoglycemic linagliptin.Isku-dubarid 1 waxay isticmaashaa methyl urea iyo cyanoacetic acid sida alaabta bilawga ah, waxayna martaa falcelinta lix-tallaabo ee uumiga, wareegga wareegga, nitrosation, hoos u dhigista, wareegga wareegga, iyo bromine oo leh wadarta guud ee 46.3%.Qaab dhismeedka dhammaan dhexdhexaadiyeyaasha waxaa xaqiijiyay 1HNMR.

Hal-abuurka hadda wuxuu la xiriiraa habka diyaarinta fudud ee linagliptin-nadiifinta sare leh.Quinazoline, dhex dhexaadiyaha muhiimka ah ee diyaarinta hal-dhari ee linagliptin 8 bromo 7 (2 butyne 1 base) 3,7 dihydro 3 methyl 1 [(4 methyl 2 quinazolinyl) methyl] 1H Purine 2,6 dione, dhexda waxaa loo kala saaraa sifaynta, ka dibna ku falcelisa (R)3 aminopiperidine dihydrochloride si loo helo xal ka kooban linagliptin.Ka dib markii xalka uu ku jiro linagliptin mar kale la farsameeyo, Deliraliptin badeeco saafi ah.Diyaarinta dhex-dhexaadka muhiimka ah ee wax-soo-saarka hadda jira wuxuu qaataa hab hal-dheri ah, kaas oo ku habboon in la shaqeeyo oo hagaajiyo wax-soo-saarka.Ka dib marka dhexdhexaadiyaha muhiimka ah la kala saaro, waxaa lagu falceliyaa (R) 3 aminopiperidine dihydrochloride, sidaas darteed Helitaanka linagliptin nadiif ah oo sarreeya waxay sidoo kale buuxisaa shuruudaha wax soo saarka iyo caddaynta ee shirkadaha dawooyinka.

Kaliya isku dayi mayno inteena ugu weyn si aan u siino shirkado heer sare ah iibsade kasta, laakiin sidoo kale waxaan diyaar u nahay inaan helno talo kasta oo ay bixiyaan dukaamaystayaasheena tayada Wanaagsan 99% 2-Cyanobenzyl Bromide;Alpha-Bromo-O-Toluonitrile CAS: 22115-41-9, Kooxda shirkadeena oo ay weheliso adeegsiga tignoolajiyada casriga ah waxay soo bandhigaan badeecado tayo leh oo tayo sare leh oo si heer sare ah loo jecel yahay loona qadariyo rajadayada adduunka oo dhan.
Tayo wanaagsanShiinaha 2-Cyanobenzyl Bromide Powder iyo Alpha-Bromo-O-Toluonitrile, Waxaan si adag u aaminsanahay in tignoolajiyada iyo adeegyadu ay yihiin saldhiggayaga maanta tayada ayaa abuuri doonta gidaaradayada mustaqbalka ee la isku halayn karo.Kaliya waxaan leenahay tayo ka wanaagsan oo ka sii fiican, ma gaari karnaa macaamiisheena iyo nafteena, sidoo kale.Ku soo dhawoow macaamiisha ereyga oo dhan si aad nala soo xiriirto si aad u hesho ganacsi dheeraad ah iyo xiriiro la isku halayn karo.Waxaan had iyo jeer halkan joognay ka shaqaynta dalabaadkaaga mar kasta oo aad u baahan doonto.