Guanosin

Guanosine waxaa loo isticmaalaa sida dhexe ee Valaciclovir.
Valacyclovir waa guanine analooga ah ee ka hortagga fayraska.Waxaa loo isticmaalaa daawaynta kiliinikada ee herpes simplex iyo caabuqa herpes zoster ee cudurada galmada lagu kala qaado.Alaabtani waa horudhaca acyclovir.Waxaa si degdeg ah loo nuugo ka dib markii maamulka afka oo si degdeg ah isu beddelay acyclovir ee jirka.Saameynteeda fayraska waxaa ciyaara acyclovir.Ka dib markii acyclovir uu galo unugyada caabuqa ee herpes, waxay la tartantaa deoxynucleoside fayraska thymidine deoxynucleoside kinase ama cell kinase, iyo daawada waxaa fosforyled galay acyclic guanosine triphosphate firfircoon.Sida substrate-ka fayraska, acyclovir wuxuu la tartamayaa deoxyguanine triphosphate ee fayraska DNA-ga polymerase, kaas oo joojiya isku-darka DNA-da fayraska oo muujiya saamaynta fayraska.Dhaqdhaqaaqa ka hortagga fayraska ee badeecadan ee vivo way ka fiican tahay acyclovir, iyo tusaha daawaynta ee fayraska herpes simplex nooca I iyo nooca II waa 42.91% iyo 30.13% ka sarreeya acyclovir siday u kala horreeyaan.Waxa kale oo ay saameyn sare ku leedahay daaweynta fayraska varicella zoster.