Liiska Qiimaha ee Tayada Sare ee Antiviral Entecavir Powder CAS 142217-69-4 oo leh Qiimaha ugu Wanaagsan

Waxaan sidoo kale soo bandhignaa soo saarista badeecada ama adeegga iyo shirkadaha xoojinta duulimaadka.Waxaan leenahay xafiis wax soo saar oo noo gaar ah.Waxaan si fudud ku siin karnaa ku dhawaad ​​nooc kasta oo baayacmushtar ah oo la mid ah noocyada kala duwan ee alaabtayada ee PriceList for High Quality Antiviral Entecavir Powder CAS 142217-69-4 oo leh Qiimaha ugu Wanaagsan oo leh kala duwanaansho qiimo leh.Weydiin kasta ama faallo kasta si weyn ayaa loogu mahadcelinayaa.Xusuusnow inaad nagu qabsato si xor ah.
Waxaan sidoo kale soo bandhignaa soo saarista badeecada ama adeegga iyo shirkadaha xoojinta duulimaadka.Waxaan leenahay xafiis wax soo saar oo noo gaar ah.Waxaan si sahlan ku siin karnaa ku dhawaad ​​nooc kasta oo badeecooyin ah oo la mid ah noocyada kala duwan ee alaabtayadaShiinaha Entecavir iyo 142217-69-4, Waxaan si diiran u soo dhawaynaynaa macaamiisha gudaha iyo dibadda inay soo booqdaan shirkadeena oo ay la yeeshaan wadahadal ganacsi.Shirkadeena had iyo jeer waxay ku adkaysataa mabda'a "tayo wanaagsan, qiimo macquul ah, adeegga heerka koowaad".Waxaan diyaar u nahay inaan idinla dhisno wadashaqeyn waqti dheer, saaxiibtinimo iyo faa'iido leh.

Entecavir (SQ 34676;BMS 200475) waa xushay oo waxtar leh HBV Inhibitor.Unugyada HepG2 qiimaha EC50 waa 3.75 nM.Dawooyinkii ugu dambeeyay ee ka hortagga cagaarshowga B iyo ka-hortagga AIDS-ka.

saamaynta Entecavir

Alaabtani waa analooga guanine nucleoside, kaas oo saameyn joojin ku leh fayraska cagaarshow B (HBV) polymerase.Waxaa lagu shubi karaa fosfooraska firfircoon ee triphosphate, iyo nuska nolosha triphosphate ee unugga waa 15 saacadood.Iyada oo la tartamaysa HBV polymerase substrate-ka dabiiciga ah ee deoxyguanosine triphosphate, entecavir triphosphate waxay joojin kartaa dhammaan saddexda hawlood ee polymerase fayraska (transcriptase roga): (1) HBV polymerase bilaabista;(2) pregenomic mRNA Samaynta xuddunta taban ee qoraalka gadaasha;(3) Isku-dubaridka xadhigga togan ee HBV DNA.Joogtada xannibaadda (Ki) ee triphosphate entecavir ee HBV DNA polymerase waa 0.0012μM.Entecavir triphosphate waxay leedahay saameyn daciif ah oo ka hortag ah unugyada α, β, δ DNA polymerase iyo mitochondrial γ DNA polymerase, oo leh qiimaha Ki ee 18 ilaa 160 μM.

Astaamaha jireed iyo kiimikaad ee Entecavir

Kastamka Entecavir

Xog dheeraad ah:

Qu Qiang (PhD ee farmashiyaha kiliinikada, Waaxda Farmashiyaha, Isbitaalka Xiangya, Jaamacadda Bartamaha Koonfurta) iyo Wang Ruoguang (Dhakhtarka Daawada, Cilmi-baarista Caafimaadka ee Changsha Ruoguang) ayaa sidoo kale qoray: in nidaamka entecavir, entecavir la qaadan karo dhowr sano ama xitaa 10 sano.In ka badan sanado.Oo waxaa isticmaali kara haweenka uurka leh, oo muujinaya badbaado wanaagsan.

Marka la eego hababka farmasiga ee loo yaqaan molecular, Entecavir waxaa laga yaabaa inay leedahay saameyn ballaaran oo fayruska ka hortagga ah, oo aan waxtar u lahayn oo keliya HBV.

Waxaan sidoo kale inta badan u isticmaalnaa Entecavir si loogu daweeyo caabuqyada neef-mareenka fayraska ee rugta caafimaadka, saameyntuna waa mid cajiib ah.

Waqtigan xaadirka ah, dib-u-eegis dib-u-eegis lagu sameeyay in ka badan 500 oo bukaan COVID19 ah oo ku sugan Hubei (meel), hal qof oo keliya ayaa qaatay entecavir.Wakhtiga dhakhtarku qoray wuxuu ahaa horraantii Janaayo, ka dibna daawada waa la joojiyay.

Iyadoo la taageerayo shaqaalaha caafimaadka ee Hubei, qaar ka mid ah dhakhaatiirta asaasiga ah, ama kooxaha khatarta sare leh, oo hadda isticmaalaya Entecavir si looga hortago COVID19, ma jiro kiis caabuq ah.Dadka looga shakisan yahay inay qaadanayaan entecavir, qofna horumar uma samayn in laga helo COVID19.

Arrimaha shatiga:

Inta badan waxaa jira laba hab, 06 hab iyo 89 hab.Dhammaadka shatiyada ee habka 06 aad bay u dhakhso badan tahay (wuxuu dhacayaa 2023)!Inkasta oo qiimaha geeddi-socodku uu yar yahay, tayada ayaa ah mid aad u wanaagsan, shaqaaluhuna waxay noqon karaan kuwo xooggan, talo-bixin shakhsiyeed: Dhirta kiimikada, isticmaal habka 06 si aanad u kibrin;shirkadaha dawooyinka, ha ku daalin oo ha noqon mid aad khatar u ah.

Sannadkii 2014, Chia Tai Tianqing waxay gaadhay iib sannadkii 10 bilyan yuan iyada oo ku tiirsan dawooyinka guud sida entecavir, oo entecavir ay ka dhigan tahay 20%.

Tan iyo markii entecavir loo ogolaaday soo dejinta 2005, in ka badan 100 shirkadood oo dawooyinka gudaha ah ayaa codsaday diiwaangelinta alaabta;iyaga ka mid ah, shirkadaha wax soo saarka ee la ansixiyay waxaa ka mid ah Jiangsu Zhengda Tianqing Pharmaceutical (ku dayashada kowaad), Hainan Zhonghe Pharmaceutical, iyo Fujian Guangxi Pharmaceutical Pharmaceutical Co., Ltd. Shengtang Pharmaceutical, Jiangxi Qingfeng Pharmaceutical Pharmaceutical, Suzhou Dawnrays Pharmaceutical Pharmaceutical Shanghai Ceutical, Shandong Lukang, Zhejiang Huasheng Biopharmaceutical, Changzhi Sanbao Biochemical.

Daawooyinka, Anhui Baker Biopharmaceutical, Hunan Concord Pharmaceutical Industry, Beijing Xiehe Pharmaceutical Factory, Beijing Baiao Pharmaceutical, Xinlitai Pharmaceutical, Dongyangguang, iwm .;Laga soo bilaabo taariikhda qandaraaska, badeecadani waxay gashay darajooyinka noocyada caanka ah ee lagu dhawaaqay tan iyo 2007.

Waxaan sidoo kale soo bandhignaa soo saarista badeecada ama adeegga iyo shirkadaha xoojinta duulimaadka.Waxaan leenahay xafiis wax soo saar oo noo gaar ah.Waxaan si fudud ku siin karnaa ku dhawaad ​​nooc kasta oo baayacmushtar ah oo la mid ah noocyada kala duwan ee alaabtayada ee PriceList for High Quality Antiviral Entecavir Powder CAS 142217-69-4 oo leh Qiimaha ugu Wanaagsan oo leh kala duwanaansho qiimo leh.Weydiin kasta ama faallo kasta si weyn ayaa loogu mahadcelinayaa.Xusuusnow inaad nagu qabsato si xor ah.
Liiska Qiimaha eeShiinaha Entecavir iyo 142217-69-4, Waxaan si diiran u soo dhawaynaynaa macaamiisha gudaha iyo dibadda inay soo booqdaan shirkadeena oo ay la yeeshaan wadahadal ganacsi.Shirkadeena had iyo jeer waxay ku adkaysataa mabda'a "tayo wanaagsan, qiimo macquul ah, adeegga heerka koowaad".Waxaan diyaar u nahay inaan idinla dhisno wadashaqeyn waqti dheer, saaxiibtinimo iyo faa'iido leh.