Iibka Kulul ee Ibrutinib Dhexdhexaadiyaha N-3 CAS 330792-70-6

Iyada oo halku-dhiggan maskaxda lagu hayo, waxaan hadda u soo baxay in ay ka mid ah ilaa xad suurto gal ah technology ugu hal abuur leh, kharash-ool ah, iyo soo saarayaasha qiimaha-tartan ee Jumlo Hot Ibrutinib Intermediates N-3 CAS 330792-70-6, Waxaan rajeyneynaa in Ku siinaya alaabtayada mustaqbalka dhow, waxaadna ogaan doontaa in xigashadayadu ay tahay mid macquul ah tayada alaabtayaduna waa mid aad u fiican!
Anigoo maskaxda ku hayna halku-dhiggan, waxaan hadda noqonay mid ka mid ah kuwa ugu macquulsan ee ugu casrisan tignoolajiyada, kharash-ku-ool ah, iyo soo-saareyaasha ugu tartanka qiimaha badanShiinaha Ibrutinib N-3 iyo dhexdhexaadiyeyaasha, Ilaa hadda alaabtayada ayaa loo dhoofiyay bariga Yurub, Bariga Dhexe, Koonfur-bari, Afrika iyo Koonfurta Ameerika iwm. Waxaan leenahay 13years iibka xirfadeed iyo iibsashada qaybaha Isuzu gudaha iyo dibadda iyo lahaanshaha ee hababka hubinta qaybaha Isuzu electronic casriyeeyay.Waxaan ku ixtiraameynaa maamulaha asaasiga ah ee daacadnimada ganacsiga, mudnaanta adeegga waxaanan ku dadaali doonaa inaan siino macaamiisheena alaab tayo sare leh iyo adeeg aad u fiican.

Dhexdhexaad u ah isku-dhafka allopurinol.

Waa mid ka mid ah taxanaha pyrazole ee 3-amino-4 lagu beddelay.Waxaa loo isticmaali karaa sidii dhexdhexaad ah si loo soo saaro xeryahooda dabiiciga ah ee faa'iido leh, sida allopurinol, mid ka mid ah taxanaha pyrazolopyrimidine, tan dambe tan iyo 1963 Tan iyo markii la isticmaalo kiliinikada, waxay ahayd daawada ugu weyn ee daaweynta gout.Waqtigan xaadirka ah, waxaa jira dhowr siyaabood oo loo yaqaan 'synthesizing'

3-aminopyrazole-4-carboxamide hemisulfate ee Shiinaha, inta badan adoo ka falcelinaya malononitrile iyo triethyl orthoformate si ay u diyaariyaan ethoxymethylene malononitrile, ka dibna falcelinta hydrazine hydrate waxay soo saartaa 3-amino-4-cyanopyrazole, kaas oo ugu dambeyntii ka falceliyay si loo soo saaro sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Kiimikada Warshadaha Times, 2008, 6 (22): 39 40), wadarta guud ee dhalidda Isku-dubarid habkani waa qiyaastii 60% (waxaa lagu xisaabiyaa sida malononitrile), habkani wuxuu ku lug leeyahay falcelin saddex-tallaabo ah, tillaabooyinka waa dheer yihiin, iyo reagents-yada loo isticmaalo, sida malononitrile iyo ethoxymethylene malononitrile, waa sun badan oo qaali ah.Intaa waxaa dheer, 3-aminopyrazole-4 oo ay diyaarisay habkan - Formamide hemisulfate waxay leedahay midab ay adag tahay in la saaro oo u baahan habayn dheeraad ah, taas oo aad u adag.

Waxaa jira warbixino ku jira suugaanta shisheeye iyadoo la adeegsanayo pyridylamide hydrazone iyo ethoxymethylene malononitrile sida alaabta ceeriin si loo helo 3-amino-4-cyanopyrazole marka lagu daro iyo baaskiil wadida, ka dibna ka falcelisa sulfuric acid oo urursan si loo helo xarunta bartilmaameedka (Reuken G Jones. Falcelinta orthoesters leh xeryahooda firfircoon ee methylene [J] J Am Chem Soc. 1952,74 (5) : 4889 4891).Qalabka ugu muhiimsan ee loo isticmaalo habkan waa qaali, wax-soo-saarka fal-celinta ma aha mid sarreeya, faa'iidada wax-soo-saarka warshaduhu waa mid hooseeya.Waa in ay adagtahay.

Heerka fulinta:Heerka Ganacsiga
Dibadda:Cad-cad ama budo jaale ah

Xidhmada:25kg/durbaan
assay (HPLC) ka kooban ama ka weyn 98.0%
daahirnimada (HPLC) ka kooban ama la mid ah 99.5%

JIN DUN Medical ayaa lehShahaadada ISO oo buuxisa heerarka wax soo saarka GMP, la shaqaaleysiiyay khubarada isku dhafka daroogada ee gudaha iyo dibadda oo leh khibrad qani ah si ay u hagaan R&D ee shirkadda.

TECHNOL OGY FAA'IIDOOYINKA
●Cadaadiska Sare ee Katalytic Hydrogenation.Cadaadiska Sare ee Hydrogenolysis Falcelinta .Falcelinta Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
● Falcelinta dib u habeynta
●Go'aanka Chiral
●Heck, Suzuki,Negishi,Sonogashira .Falcelinta Gignard

Qalabka

Shaybaadhkayagu waxa uu leeyahay qalab tijaabo ah oo kala duwan, sida: NMR (Bruker 400M),HPLC,chiral-HPLC,LC-MS,LC-MS/MS (API 4000),IR,UV,GC,GC-MS, Chromatography, Mikrowave Synthesizer, Parallel Synthesizer, Kalorimeter Iskaanka Kala Duwan (DSC), Microscope Electron…

Kooxda R&D

Jindun Medical waxay leedahay koox shaqaale R&D ah oo xirfad leh, waxayna shaqaaleysiisaa khubaro badan oo gudaha iyo dibedda ah oo ku takhasusay isku-darka daroogada si ay u hagaan R&D, taasoo ka dhigaysa isku-dhafkayaga mid sax ah oo hufan.

Waxaan caawinay dhowr shirkadood oo dawooyinka gudaha ugu sarreeya, sidaHansoh, Hengrui iyo HEC Pharm.Halkan waxaan ku tusi doonaa qayb iyaga ka mid ah.

Kiiska Koowaad ee Customization:

Cas No.: 110351-94-5

Cabashada Labaad:

Cas No.: 144848-24-8

Kiiska Saddexaad ee Habaynta:

Cas No.: 200636-54-0

1.Habbee Dhexdhexaadiyeyaasha Cusub ama API-yada.Si la mid ah wadaagista kiisaska kore, macaamiishu waxay leeyihiin dalabaadka Dhexdhexaadiyeyaasha gaarka ah ama API-yada, mana ka heli karaan badeecadaha loo baahan yahay suuqa, ka dib waxaan ku caawin karnaa si aan u habeyno.

2.Habraaca Hagaajinta Alaabta Hore.Kooxdayadu waxay gacan ka geysan doontaa in ay wanaajiso oo ay hagaajiso wax soo saarka noocaas ah oo dariiqa falcelinta ee duugoobay, qiimaha wax soo saarku uu sarreeyo, waxtarkeeduna uu yar yahay.Waxaan ku siin karnaa dukumeenti buuxa oo wareejinta tignoolajiyada iyo hagaajinta habka, ka caawinta macaamiisha wax soo saar hufan.

Laga soo bilaabo bartilmaameedyada daroogada ilaa INDs, JIN DUN Medical ayaa ku siinaysaXalka R&D shaqsiyeysan ee hal-joojin ah.

JIN DUN Medical waxay ku adkaysanaysaa abuurista koox riyooyin leh, samaynta alaab sharaf leh, taxadar leh, adag, iyo u bixista dhammaan si ay u noqoto lammaane la aamini karo iyo saaxiibka macaamiisha!

Iyada oo halku-dhiggan maskaxda lagu hayo, waxaan hadda u soo baxay in ay ka mid ah ilaa xad suurto gal ah technology ugu hal abuur leh, kharash-ool ah, iyo soo saarayaasha qiimaha-tartan ee Jumlo Hot Ibrutinib Intermediates N-3 CAS 330792-70-6, Waxaan rajeyneynaa in Ku siinaya alaabtayada mustaqbalka dhow, waxaadna ogaan doontaa in xigashadayadu ay tahay mid macquul ah tayada alaabtayaduna waa mid aad u fiican!
JumloShiinaha Ibrutinib N-3 iyo dhexdhexaadiyeyaasha, Ilaa hadda alaabtayada ayaa loo dhoofiyay bariga Yurub, Bariga Dhexe, Koonfur-bari, Afrika iyo Koonfurta Ameerika iwm. Waxaan leenahay 13years iibka xirfadeed iyo iibsashada qaybaha Isuzu gudaha iyo dibadda iyo lahaanshaha ee hababka hubinta qaybaha Isuzu electronic casriyeeyay.Waxaan ku ixtiraameynaa maamulaha asaasiga ah ee daacadnimada ganacsiga, mudnaanta adeegga waxaanan ku dadaali doonaa inaan siino macaamiisheena alaab tayo sare leh iyo adeeg aad u fiican.