4-chloro-n- (4,5-dihydro-1h-imidazol-2-yl) -6-methoxy-2-methyl-5-pyrimidinamin;
4-chloro-n- (4,5-dihydro-1h-imidazol-2-yl) -6-methoxy-2-methyl-5-pyrimidinamin;
Waxay u shaqeysaa iyadoo kicinaysa xarunta dhexe ee presynaptic alpha 2- reseptors.Saameynteeda hypotensive waxay la mid tahay tan nifedipine, kalsiyum antagonist, iyo captopril, ACE inhibitor.Dhiig karka lagama maarmaanka u ah.
Alaabtani waa inay qaadato mabda'a daawaynta shakhsi ahaaneed.Guud ahaan ka bilow qiyaasta ugu hooseeya, taas oo ah, 0.2mg, hal mar maalintii, oo la qaato subaxdii.Hagaajinta qiyaasta qiyaasta waa in la sameeyaa saddex toddobaad gudahood ilaa natiijooyin lagu qanco laga helayo.Qiyaasta caadiga ah waa 0.2mg hal mar, laba jeer maalintii (subaxda iyo fiidkii).Qiyaasta ugu badan ee wakhti kasta waa in aanay dhaafin 0.4mg, iyo qiyaasta maalinlaha ah ee ugu badan waa in aanay ka badnayn 0.6mg.Bukaanka qaba yaraanta kelyaha ee khafiifka ah ama dhexdhexaadka ah, hal dose waa in aanu dhaafin 0.2 mg ama qiyaasta maalinlaha ah waa in aanay ka badnayn 0.4 mg.
Alaabtani waa agonist α2-receptor, kaas oo ah daawada antihypertensive imidazoline.Loo isticmaalo dhiig-karka hoose iyo dhexe ee dhexdhexaadka ah iyo kan daran.
Sababtoo ah waxay joojisaa dheecaanka iyo dhaqdhaqaaqa mareenka caloosha iyo mindhicirka, waxay sidoo kale ku habboon tahay bukaannada hypertensive ee ka cabanaya cudurrada boogaha.Isku darka daawadan iyo dawooyinka lagu durayo ayaa si weyn u wanaajin kara waxtarka.Waa dawo dhexe oo xoog leh oo ka hortagta hypertensive iyo safka labaad ee daawada hypertensive.Waxaa inta badan lagu maamulaa gudaha gudaha baarista indhaha.Alaabtani waxay leedahay saamaynta hoos u dhigista cadaadiska intracular, oo ma saameynayso ardayga iyo habka toosinta indhaha.Waxay xannibi kartaa xididdada dhiigga ee isha, waxay yaraynaysaa wax soo saarka kaftanka aqueous, waxayna gaadhi kartaa saamaynta yaraynta cadaadiska indhaha.Waxay bilaabataa inay dhaqan gasho 15 daqiiqo ka dib marka isha hoos u dhacdo waxayna sii wadi kartaa saamaynta ilaa 8 saacadood.
Heerka:EP10
Nuxurka qiimaynta:97.5-102.0%
Dibadda:Caddaan ama ku dhawaad inta budada ah
Xidhmada:1kg/bac ama sida ay macaamiishu rabaan
JIN DUN Medical ayaa lehShahaadada ISO oo buuxisa heerarka wax soo saarka GMP, la shaqaaleysiiyay khubarada isku dhafka daroogada ee gudaha iyo dibadda oo leh khibrad qani ah si ay u hagaan R&D ee shirkadda.
TECHNOL OGY FAA'IIDOOYINKA
●Cadaadiska Sare ee Katalytic Hydrogenation.Cadaadiska Sare ee Hydrogenolysis Falcelinta .Falcelinta Cryogenic (<-78%C)
●Aromatic Heterocyclic Synthesis
● Falcelinta dib u habeynta
●Go'aanka Chiral
●Heck, Suzuki,Negishi,Sonogashira .Falcelinta Gignard
Qalabka
Shaybaadhkayagu waxa uu leeyahay qalab tijaabo ah oo kala duwan, sida: NMR (Bruker 400M),HPLC,chiral-HPLC,LC-MS,LC-MS/MS (API 4000),IR,UV,GC,GC-MS, Chromatography, Mikrowave Synthesizer, Parallel Synthesizer, Kalorimitirka Iskaanka Kala Duwan (DSC), Microscope Electron...
Kooxda R&D
Jindun Medical waxay leedahay koox shaqaale R&D ah oo xirfad leh, waxayna shaqaaleysiisaa khubaro badan oo gudaha iyo dibedda ah oo ku takhasusay isku-darka daroogada si ay u hagaan R&D, taasoo ka dhigaysa isku-dhafkayaga mid sax ah oo hufan.
Waxaan caawinay dhowr shirkadood oo dawooyinka gudaha ugu sarreeya, sidaHansoh, Hengrui iyo HEC Pharm.Halkan waxaan ku tusi doonaa qayb iyaga ka mid ah.
Kiiska Koowaad ee Customization:
Cas No.: 110351-94-5
Cabashada Labaad:
Cas No.: 144848-24-8
Kiiska Saddexaad ee Habaynta:
Cas No.: 200636-54-0
1.Habbee Dhexdhexaadiyeyaasha Cusub ama API-yada.Si la mid ah wadaagista kiisaska kore, macaamiishu waxay leeyihiin dalabaadka Dhexdhexaadiyeyaasha gaarka ah ama API-yada, mana ka heli karaan badeecadaha loo baahan yahay suuqa, ka dib waxaan ku caawin karnaa si aan u habeyno.
2.Habraaca Hagaajinta Alaabta Hore.Kooxdayadu waxay gacan ka geysan doontaa in ay wanaajiso oo ay hagaajiso wax soo saarka noocaas ah oo dariiqa falcelinta ee duugoobay, qiimaha wax soo saarku uu sarreeyo, waxtarkeeduna uu yar yahay.Waxaan ku siin karnaa dukumeenti buuxa oo wareejinta tignoolajiyada iyo hagaajinta habka, ka caawinta macaamiisha wax soo saar hufan.
Laga soo bilaabo bartilmaameedyada daroogada ilaa INDs, JIN DUN Medical ayaa ku siinaysaXalka R&D shaqsiyeysan ee hal-joojin ah.
JIN DUN Medical waxay ku adkaysanaysaa abuurista koox riyooyin leh, samaynta alaab sharaf leh, taxadar leh, adag, iyo u bixista dhammaan si ay u noqoto lammaane la aamini karo iyo saaxiibka macaamiisha!
