8-Bromo-7-laakin-2-ynyl-3-methyl-1- (4-methyl-quinazolin-2-ylmethyl) -3

Si loo falanqeeyo linagliptin-ka jira iyo furaha dhexe ee 8-bromo-7- (2-butynyl) -3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl) methyl) -1H-purine- 2,6-dione (11) habka synthesis, hel waddo synthetic ah oo ku habboon wax soo saarka warshadaha.Habka: soo koob waddooyinka kala duwan ee synthetic.Natiijooyinka iyo gabagabada: Marinka 2.2 wuxuu leeyahay hannaan fudud iyo kharash yar, kaas oo ku habboon wax soo saarka warshadaha.

8-bromo-3,7-dihydro-3-methyl-1H-purine-2,6-dione waa dhex dhexaad muhiim ah oo ka mid ah isku dhafka daawada hypoglycemic linagliptin.Isku-dubarid 1 waxay isticmaashaa methyl urea iyo cyanoacetic acid sida alaabta bilawga ah, waxayna martaa falcelinta lix-tallaabo ee uumiga, wareegga wareegga, nitrosation, hoos u dhigista, wareegga wareegga, iyo bromine oo leh wadarta guud ee 46.3%.Qaab dhismeedka dhammaan dhexdhexaadiyeyaasha waxaa xaqiijiyay 1HNMR.

Hal-abuurka hadda wuxuu la xiriiraa habka diyaarinta fudud ee linagliptin-nadiifinta sare leh.Quinazoline, dhex dhexaadiyaha muhiimka ah ee diyaarinta hal-dhari ee linagliptin 8 bromo 7 (2 butyne 1 base) 3,7 dihydro 3 methyl 1 [(4 methyl 2 quinazolinyl) methyl] 1H Purine 2,6 dione, dhexda waxaa loo kala saaraa sifaynta, ka dibna ku falcelisa (R)3 aminopiperidine dihydrochloride si loo helo xal ka kooban linagliptin.Ka dib markii xalka uu ku jiro linagliptin mar kale la farsameeyo, Deliraliptin badeeco saafi ah.Diyaarinta dhex-dhexaadka muhiimka ah ee wax-soo-saarka hadda jira wuxuu qaataa hab hal-dheri ah, kaas oo ku habboon in la shaqeeyo oo hagaajiyo wax-soo-saarka.Ka dib marka dhexdhexaadiyaha muhiimka ah la kala saaro, waxaa lagu falceliyaa (R) 3 aminopiperidine dihydrochloride, sidaas darteed Helitaanka linagliptin nadiif ah oo sarreeya waxay sidoo kale buuxisaa shuruudaha wax soo saarka iyo caddaynta ee shirkadaha dawooyinka.